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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

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Insulin resistance is a hallmark of type 2 diabetes and often precedes its development, where cells become less responsive to insulin's signal to take up glucose from the bloodstream

Younger individuals with a significant family history or other predisposing factors may warrant earlier or more intensive screening protocols